Phenome-wide
WebMar 15, 2024 · Results of the phenome-wide association study for clinical outcomes in the UK Biobank and validation in the Penn Medicine BioBank and BioMe Biobank, and for … WebApr 12, 2024 · A phenome-wide Mendelian randomization (MR) study of anti-VZV immunoglobulin G (IgG) levels with 1370 traits was conducted to explore the potential causal role of VZV-specific immune response on multiple traits using the UK Biobank cohort. For the robustness of the results, we performed MR analyses using five different …
Phenome-wide
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WebJun 15, 2024 · With the advances in genotyping technologies and electronic health records (EHRs), large biobanks have been great resources to identify novel genetic associations and gene-environment interactions on a genome-wide and even a phenome-wide scale. To date, several phenome-wide association studies (PheWAS) have been performed on biobank … WebMar 5, 2024 · Phenome-wide association study to explore the long-term symptoms after infection with novel coronavirus in the UK Biobank medRxiv Phenome-wide association study to explore the long-term symptoms after infection with novel coronavirus in the UK Biobank Kai Zhang, Xiaowen Liu, Ping Fu, Yingqi Zhao, Qingqing Yu, Shuling Liu, Fuzhong …
WebAug 15, 2014 · Phenome-wide association studies (PheWAS) have been used to replicate known genetic associations and discover new phenotype associations for genetic variants. WebJul 31, 2024 · Methods A phenome-wide Mendelian randomization study (MR-PheWAS) of anti-VZV Immunoglobulin G (IgG) level with 1,370 traits was conducted to explore the potential causal role of VZV-specific immunity on multiple traits using the UK Biobank cohort. For each trait, we performed Mendelian randomization (MR) analyses using five …
WebMar 1, 2024 · Methods. First, we performed a phenome-wide association study (PheWAS) to investigate the associations of genetically predicted plasma concentrations (genetic component of the circulating concentrations) of folate, vitamin B6, vitamin B12, and their metabolite homocysteine with a wide range of disease outcomes (including both … WebAlterations in eating behavior characterized eating disorders (ED). The genetic factors shared between ED diagnoses have been underexplored. The present study performed a genome-wide association study in individuals with disordered eating behaviors in the Mexican population, blood methylation quantitative trait loci (blood-meQTL), summary …
WebSep 7, 2024 · Drug target prioritization and repositioning using phenome-wide MR Given that human proteins represent the major source of therapeutic targets, we sought to mine our …
In genetics and genetic epidemiology, a phenome-wide association study, abbreviated PheWAS, is a study design in which the association between single-nucleotide polymorphisms or other types of DNA variants is tested across a large number of different phenotypes. The aim of PheWAS studies (or PheWASs) is to examine the causal linkage between known sequence differences and any type of trait, including molecular, biochemical, cellular, and especially clinical diagnoses and … illinois mega millions winning numbers pastWebMar 29, 2024 · Phenome-wide Mendelian randomization study of plasma triglyceride levels and 2600 disease traits - PMC Back to Top Skip to main content An official website of the United States government Here's how you know The .gov means it’s official. Federal government websites often end in .gov or .mil. illinois mennonite conference websiteWebMay 13, 2024 · Our large-scale phenome-wide approach identifies clusters of diseases which may be indicative of underlying biological mechanisms of COVID-19 disease … illinois med mal lawyerWebPhenome-Wide Association Studies Genetics and Genomics JAMA JAMA Network Scheduled Maintenance Our websites may be periodically unavailable between 7:00 pm CT April 8, 2024 and 1:00 am CT April 9, 2024 for regularly scheduled maintenance. illinois men basketball scheduleWebPhenome-wide association study (PheWAS) has been increasingly used to identify novel genetic associations across a wide spectrum of phenotypes. This systematic review … illinois mental health code confidentialityillinois mens basketball schedule 2022 2023WebAug 31, 2016 · In addition to disease and trait genetics, EHRs proved a valuable resource for analyzing pharmacogenetic traits and developing reverse genetics approaches such as phenome-wide association studies (PheWASs). PheWASs are designed to survey which of many phenotypes may be associated with a given genetic variant. illinois mental health collaborative crss