Web1 dec. 2003 · Megalin was first identified by Kerjaschki and Farquhar and later found to be a member of the low-density lipoprotein receptor family, composed of a single-transmembrane domain, a large ectodomain, and a short cytoplasmic tail (10–12).Megalin mediates tubular uptake of low-molecular-weight proteins in the kidney and is also involved in the … Web11 jul. 2014 · Megalin plays a particular key role in the proximal tubular uptake of glomerular-filtered albumin and other low-molecular-weight-proteins. Consistent with this function, megalin knockout mice develop low-molecular-weight proteinuria and albuminuria [ …
Preferential megalin-mediated transcytosis of low-hormonogenic …
Web19 jan. 2024 · Thus, substitution of L12-L14 to A12-A14 does not impede megalin’s trafficking to the mitochondria and is not expected to interfere with megalin functions that are independent of STC1 binding ... WebMegalin is an endocytic receptor expressed on the apical surface of several epithelial cells that internalizes a variety of ligands including nutrients, hormones and their carrier … gibby ice cream worcester ma
Megalin - an overview ScienceDirect Topics
Web1 apr. 2001 · Megalin serves important functions in calcium homeostasis. As described, megalin mediates proximal tubule endocytosis of the DBP-vitamin D complex, resulting in the renal hydroxylation and activation of vitamin D . In addition, megalin mediates tubular uptake and subsequent lysosomal degradation of PTH . Web26 jan. 2016 · Impairment of megalin function, even in the early stages of diabetes, has been observed in rat animal models as well as in patients [78–80]. Streptozotocin-induced diabetic rats had decreased protein expression of megalin at the apical membrane of proximal convoluted tubule cells. Web30 mrt. 2004 · Dent disease is characteristic for the urinary loss of low-molecular-weight proteins and calcium, leading to renal calcification and, in some patients, chronic renal failure. This disorder is caused by loss-of-function mutations in the renal chloride channel gene, CLCN5. The animal model of this disease has demonstrated the possible role of … gibby lacasse