Irinotecan ic50
WebMay 31, 2024 · Similarly, the IC50 of gimatecan in all chosen cell lines ranged from 4.9 ± 0.47 nM to 39.6 ± 0.32 nM, which were lower than that of irinotecan (8140 ± 366–37,680 ± 521 nM), demonstrating that... WebIrinotecan (Camptosar, Campto, CPT-11) is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively. Targets LoVo cells HT-29 …
Irinotecan ic50
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http://beloranib.net/tag/irinotecan-ic50/ WebDec 21, 2024 · SN 38 is anctive metabolite of CPT-11 that inhibits DNA topoisomerase I (IC50 values are 0.74 and 1.9 μM in P388 and Ehrlich cells respectively). During hydrolysis, SN 38 is formed when the carboxylesterases metabolize irinotecan through glucuronidation by UDP glucuronosyl transferase 1A1. Compared to irinotecan, SN 38 is a more potent ...
WebMay 22, 2024 · Background We investigated the role of the ETS-1 transcription factor in Head and Neck Squamous Cell Carcinoma (HNSCC) in multiple cisplatin-resistant HNSCC cell lines. Methods We examined its molecular link with SRC and MEK/ERK pathways and determined the efficacy of either MEK/ERK inhibitor PD0325901 or SRC inhibitor Dasatinib … WebIrinotecan (CPT-11), a prodrug for treating metastatic colorectal cancer, is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively …
WebA- IC50 values after in vitro exposure for 30 min of CRC cells SW480, HT28, HCT116 and HCT8 with Oxaliplatin, 5 FU, Cisplatin, GEM, Irinotecan and Raltitrexed. B- Dose-response curves after... WebIrinotecan (CPT-11, (+)-Irinotecan) is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively. Camptothecin (NSC-100880, CPT, …
WebJul 23, 2014 · Irinotecan is a potent inhibitor of DNA topoisomerase 1 ( 5) and has been reported to be active in recurrent SCLC patients in several Phase II trials. Patients were treated with irinotecan at a dosage of 100–125 mg/m 2 weekly or 350 mg/m 2 on Day 1 every 3 weeks in these studies ( 6–9 ).
WebApr 14, 2024 · IC 50 value of irinotecan was more than 50 μM for 24 hours, while for 48 hours and 72 hours exhibited IC 50 41.69 ± .025 μM and 9.46 ± .108 μM, respectively, against HT 29 (Figure 6 and Table 2). ... The response dose curve graph was plotted to obtain the IC50 value. The cell viability was calculated as follows how many hours is evil westWebIrinotecan has been administered by intratumoral injection at 0.1 cc volume of the appropriate solution, for a doses of 5 mg/kg daily for 5 days, on two consecutive weeks, followed by a 7-days rest period, referred to as one cycle of therapy.Rats receive three cycles over a period of 8 weeks. Control animals receive 0.1 cc of sterile 0.9% sodium chloride … how animals are affected by fireworksWebDec 1, 2024 · Camptothecin (CPT) was discovered from plant extracts more than 60 years ago. Since then, only two CPT analogues (irinotecan and topotecan) have been approved for cancer treatment, although several thousand CPT derivatives have been synthesized and many of them were actively studied in our research community over the past 6+ decades. how animals adapt animal atlasWeb特别声明：本产品及我公司所售其他产品均为科研类试剂产品，严禁用于药物、医疗及其他非科研用途。 DNA解旋抑制剂(Irinotecan)厂家现货的品牌：百奥莱博，是优质的抑制剂激活剂产品，用于科研实验，本产品质量好，且极具价格优势，深为用户称道，了解更多DNA解旋抑 … how animals adapt to the heatWebDrug: Irinotecan - Cancerrxgene - Genomics of Drug Sensitivity in Cancer Genomics of Drug Sensitivity in Cancer Compound: Irinotecan Drug Target: TOP1 Drug Target pathway: DNA … how many hours is fcr 110 training classWebProliferative effects on colorectal cancer cell lines plotted as IC50 following exposure to the PI3K/mTORi, PF-04691502 (0–5 umol/L). Cells were plated in 96 well plates and allowed to adhere... how animals adapt to the rainforestWebMar 1, 2001 · Results: Irinotecan was investigated as second-line chemotherapy after prior treatment with fluorouracil (FU)-based regimens in two large randomized phase III trials comparing irinotecan with either best supportive care or … how animals and humans are alike